ABSTRACT
E relatada a experiência pessoal do autor de abordagem de casos índices de estados psicóticos esquizofrênicos, utilizando novo fármaco e penfluridol.
It's related index cases of personal experience with perfluridol. A new drug was utilized with success in the psicotic states of schizophrenia.
Subject(s)
Humans , Schizophrenia/drug therapy , Penfluridol/therapeutic useABSTRACT
O autor analisa o advento dos neurolépticos e suas conseqüências. Faz ampla revisão do tema abordando a farmacologia destas substâncias, os aspectos clínicos, principais indicações e efeitos colaterais. Conclui mostrando o verdadeiro alcance antimanicomial dos neurolépticos
Subject(s)
Anticonvulsants , Chlorpromazine , Chlorprothixene , Clopenthixol , Clozapine , Flupenthixol , Fluphenazine , Fluspirilene , Haloperidol , Methotrimeprazine , Penfluridol , Perphenazine , Pimozide , Promazine , Promethazine , Reserpine , Sulpiride , Thioridazine , Thiothixene , TrifluperidolABSTRACT
Thirty chronic schizophrenic patients completed 12 week treatment with a single weekly dose of 20 mg penfluridol, a new long acting oral neuroleptic. The patients were evaluated by using modified rating scale. Significant reduction in scores was demonstrated in 15 out of 26 symptom variables. Few side effects were reported which were easily controlled by conventional antiparkinson agents. Laboratory investigations remained within normal limits.
Subject(s)
Administration, Oral , Adult , Drug Administration Schedule , Drug Evaluation , Humans , Penfluridol/administration & dosage , Schizophrenia/drug therapyABSTRACT
A double blind comparative study was conducted to evaluate the efficacy and safety of penfluridol and trifluoperazine in patients of chronic schizophrenia. Penfluridol was administered once weekly while trifluoperazine was administered twice daily by preparing identical capsules. The data revealed that both the compounds were similarly effective in maintaining control of symptoms of chronic schizophrenia. However, penfluridol has a definite advantage over trifluoperazine since it is administered once a week instead of twice a day.
Subject(s)
Adult , Clinical Trials as Topic , Double-Blind Method , Drug Administration Schedule , Fatigue/chemically induced , Female , Humans , Male , Penfluridol/administration & dosage , Piperidines/therapeutic use , Random Allocation , Schizophrenia/drug therapy , Schizophrenic Psychology , Sleep Initiation and Maintenance Disorders/chemically induced , Trifluoperazine/administration & dosageABSTRACT
Con el objeto de evaluar el efecto antipsicotico y resocializador del neuroleptico de accion prolongada penfluridol, veinte pacientes esquizofrenicos fueron tratados durante un ano, y paralelamente al seguimiento clinico se efectuo una evaluacion de los aspectos psicosociales a cargo de una asistente social psiquiatrica. Se analizo la reinsercion del paciente en su medio familiar, su comportamiento social y su reincorporacion laboral, para lo que se disenaron instrumentos especificos. Despues de un ano de tratamiento se observo que junto con la mejoria clinica, se produjeron cambios muy significativos en todos los aspectos del comportamiento social estudiados. Se senala ademas, que el manejo familiar reduce el abandono del tratamiento y con ello la frecuencia de recaida.Se resumen, por ultimo,algumas observaciones preliminares sobre la estructura y dinamica y los cambios que ocurren en esta con el tratamiento del paciente psicotico